Spinal Cord Injury Repair: NSCs Migration Promoted and Drug Delivered Exosomes?Collagen Scaffold via a Bio?Specific Peptide for One?Step Spinal Cord Injury Repair (Adv. Healthcare Mater. 8/2021)
نویسندگان
چکیده
To achieve one-step spinal cord injury (SCI) repairs, in article number 2001896 and Yanyan Chen, Jianwu Dai, co-workers, a scaffold-retained paclitaxel-loaded exosome from mesenchymal stem cells (MExos) is established. Benefiting the synergistic effects of endogenous NSCs recruitment differentiation into neurons induced by MExos paclitaxel respectively injured site, this multifunctional scaffold shows superior performance for motor functional recovery after complete SCI rats.
منابع مشابه
P48: Self-Assembling Peptide Nanostructures as a Good Scaffold for Treatment of Spinal Cord Injury
لطفاً به چکیده انگلیسی مراجعه شود.
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Advances in medical and rehabilitative care now allow the 10-12,000 individuals who suffer spinal cord injuries each year in the United States to lead productive lives of nearly normal life expectancy, so that the numbers of those with chronic injuries will approximate 300,000 at the end of the next decade. This signals an urgent need for new treatments that will improve repair and recovery aft...
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The failure of axons in the central nervous system (CNS) to regenerate has been considered the main factor limiting recovery from spinal cord injury (SCI). Impressive gains in identification of growth-inhibitory molecules in the CNS led to expectations that their neutralization would lead to functional regeneration. However, results of therapeutic approaches based on this assumption have been m...
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ژورنال
عنوان ژورنال: Advanced Healthcare Materials
سال: 2021
ISSN: ['2192-2640', '2192-2659']
DOI: https://doi.org/10.1002/adhm.202170034